Structure of PDB 1vsi Chain A Binding Site BS01

Receptor Information
>1vsi Chain A (length=146) Species: 11889 (Rous sarcoma virus (strain Schmidt-Ruppin)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVAAQH
HWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNSQGQ
AMVERANRLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHF
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1vsi Chain A Residue 280 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1vsi Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		D64 D121
Binding residue
(residue number reindexed from 1)		D11 D68
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:1vsi, PDBe:1vsi, PDBj:1vsi
PDBsum1vsi
PubMed9218451
UniProtO92956|POL_RSVSB Gag-Pol polyprotein (Gene Name=gag-pol)

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