Structure of PDB 1vrc Chain A Binding Site BS01

Receptor Information

>1vrc Chain A (length=129) Species: 562 (Escherichia coli)

TIAIVIGTHGWAAEQLLKTAEMLLGEQENVGWIDFVPGENAETLIEKYNA
QLAKLDTTKGVLFLVDTWGGSPFNAASRIVVDKEHYEVIAGVNIPMLVET
LMARDDDPSFDELVALAVETGREGVKALK

Ligand information

• Ligand ID: PO3
• InChI: InChI=1S/O3P/c1-4(2)3/q-3
• InChIKey: AQSJGOWTSHOLKH-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [O-][P-]([O-])=O
  ACDLabs 10.04: [O-][PH2-]([O-])=O
  OpenEye OEToolkits 1.5.0: [O-][P-](=O)[O-]
• Formula: O3 P
• Name: PHOSPHITE ION
• PDB chain: 1vrc Chain D Residue 400

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1vrc Solution NMR structure of the 48-kDa IIAMannose-HPr complex of the Escherichia coli mannose phosphotransferase system.
• Resolution: N/A
• Binding residue (original residue number in PDB): H10 F36 G71 S72
• Binding residue (residue number reindexed from 1): H9 F35 G70 S71
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.1.191: protein-N(pi)-phosphohistidine--D-mannose phosphotransferase.

Gene Ontology

Molecular Function

• GO:0016773 phosphotransferase activity, alcohol group as acceptor

Biological Process

• GO:0008643 carbohydrate transport
• GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system

Cellular Component

• GO:0005737 cytoplasm
• GO:0016020 membrane

External links

• PDB: RCSB:1vrc, PDBe:1vrc, PDBj:1vrc
• PDBsum: 1vrc
• PubMed: 15788390
• UniProt: P69797|PTNAB_ECOLI PTS system mannose-specific EIIAB component (Gene Name=manX)