Structure of PDB 1vjo Chain A Binding Site BS01

Receptor Information

>1vjo Chain A (length=377) Species: 103690 (Nostoc sp. PCC 7120 = FACHB-418)

ISINDNQRLQLEPLEVPSRLLLGPGPSNAHPSVLQAMNVSPVGHLDPAFL
ALMDEIQSLLRYVWQTENPLTIAVSGTGTAAMEATIANAVEPGDVVLIGV
AGYFGNRLVDMAGRYGADVRTISKPWGEVFSLEELRTALETHRPAILALV
HAETSTGARQPLEGVGELCREFGTLLLVDTVTSLGGVPIFLDAWGVDLAY
SCSQKGLGCSPGASPFTMSSRAIEKLQRRRTKVANWYLDMNLLGKYWGSE
RVYHHTAPINLYYALREALRLIAQEGLANCWQRHQKNVEYLWERLEDIGL
SLHVEKEYRLPTLTTVCIPDGVDGKAVARRLLNEHNIEVGGGLGELAGKV
WRVGLMGFNSRKESVDQLIPALEQVLR

Ligand information

• Ligand ID: PLP
• InChI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
• InChIKey: NGVDGCNFYWLIFO-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
  OpenEye OEToolkits 1.5.0: Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
  ACDLabs 10.04: O=P(O)(O)OCc1cnc(c(O)c1C=O)C
• Formula: C8 H10 N O6 P
• Name: PYRIDOXAL-5'-PHOSPHATE;
  VITAMIN B6 Phosphate
• ChEMBL: CHEMBL82202
• DrugBank: DB00114
• ZINC: ZINC000001532514
• PDB chain: 1vjo Chain A Residue 400

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1vjo Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): T81 G82 T83 F108 T158 D183 V185 K209
• Binding residue (residue number reindexed from 1): T77 G78 T79 F104 T154 D179 V181 K205
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.6.1.44: alanine--glyoxylate transaminase.

Gene Ontology

Molecular Function

• GO:0004760 L-serine-pyruvate transaminase activity
• GO:0008453 alanine-glyoxylate transaminase activity
• GO:0008483 transaminase activity

Biological Process

• GO:0019265 glycine biosynthetic process, by transamination of glyoxylate

Cellular Component

• GO:0005777 peroxisome

External links

• PDB: RCSB:1vjo, PDBe:1vjo, PDBj:1vjo
• PDBsum: 1vjo
• PubMed: 15657930
• UniProt: Q8YY48