Structure of PDB 1vj7 Chain A Binding Site BS01

Receptor Information
>1vj7 Chain A (length=326) Species: 119602 (Streptococcus dysgalactiae subsp. equisimilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INLTGEEVVALAAKYMNETDAAFVKKALDYATAAHFYQVRKSGEPYIVHP
IQVAGILADLHLDAVTVACGFLHDVVEDTDITLDNIEFDFGKDVRDIVDG
VTKLGHRKMLMAMSKDIRVILVKLADRLHNMRTLKQERISRETMEIYAPL
AHRLGISRIKWELEDLAFRYLNETEFYKISHMMNEKRREREALVDDIVTK
IKSYTTEQGLFGDVYGRPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMET
QSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVYGPKGPIEI
QIRTKEMHQVAEYGVAANWIKELVEL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1vj7 Chain A Residue 997 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1vj7 Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		H53 H77 D144
Binding residue
(residue number reindexed from 1)		H49 H73 D126
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.6.5: GTP diphosphokinase.
3.1.7.2: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase.
Gene Ontology
Biological Process
GO:0015969 guanosine tetraphosphate metabolic process

View graph for
Biological Process
External links
PDB RCSB:1vj7, PDBe:1vj7, PDBj:1vj7
PDBsum1vj7
PubMed15066282
UniProtQ54089|RELA_STREQ Bifunctional (p)ppGpp synthase/hydrolase RelA (Gene Name=relA)

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