Structure of PDB 1vfe Chain A Binding Site BS01

Receptor Information
>1vfe Chain A (length=321) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVQWCAVSQPEATKCFQWQRNMRRVRGPPVSCIKRDSPIQCIQAIAENRA
DAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSF
QLNELQGLKSCHTGLRSTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFS
ASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAG
DVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHA
VVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSA
IGFSRVPPRIDSGLYLGSGYF
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain1vfe Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1vfe Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: crystal structures of R121S and R121E mutants.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D60 Y92 Y192 H253
Binding residue
(residue number reindexed from 1)		D56 Y88 Y188 H249
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.-
Gene Ontology
Cellular Component
GO:0005576 extracellular region

View graph for
Cellular Component
External links
PDB RCSB:1vfe, PDBe:1vfe, PDBj:1vfe
PDBsum1vfe
PubMed8931543
UniProtP02788|TRFL_HUMAN Lactotransferrin (Gene Name=LTF)

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