Structure of PDB 1v6a Chain A Binding Site BS01

Receptor Information
>1v6a Chain A (length=332) Species: 7962 (Cyprinus carpio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASTKEKLITHVSKEEPAGPTNKVTVVGVGMVGMAAAISILLKDLTDELAL
VDVMEDKLKGEAMDLQHGSLFLKTHKIVADKDYSVTANSKVVVVTAGARQ
QEGESRLNLVQRNVNIFKFIIPNIIKYSPNCILLVVSNPVDILTYVAWKL
SGLPRNRVIGSGTNLDSARFRHLMGEKLGIHPSNCHGWVIGEHGDSSVPV
WSGVNVAGVFLQGLNPDMGTDKDKEDWKSVHKMVVDSAYEVIKLKGYTSW
AIGMSAADLCQSILKNLRKCHPVSTLVKGMHGVNEEVFLSVPCILGNSGL
TDVVHMTLKSDEEKQLVKSAETLWGVQKDLTL
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain1v6a Chain C Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1v6a Crystal Structure of L-lactate dehydrogenase from Cyprinus carpio
Resolution2.3 Å
Binding residue
(original residue number in PDB)		E47 S84 V85
Binding residue
(residue number reindexed from 1)		E47 S84 V85
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) R106 D166 R169 H193
Catalytic site (residue number reindexed from 1) R106 D166 R169 H193
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:1v6a, PDBe:1v6a, PDBj:1v6a
PDBsum1v6a
PubMed
UniProtQ9W7K5|LDHA_CYPCA L-lactate dehydrogenase A chain (Gene Name=ldha)

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