Structure of PDB 1v2i Chain A Binding Site BS01

Receptor Information

>1v2i Chain A (length=431) Species: 11216 (Human respirovirus 3)

ITHDVGIKPLNPDDFWRCTSGLPSLMKTPKIRLMPGPGLLAMPTTVDGCI
RTPSLVINDLIYAYTSNLITRGCQDIGKSYQVLQIGIITVNSDLVPDLNP
RISHTFNINDNRKSCSLALLNTDVYQLCSTPKVDERSDYASPGIEDIVLD
IVNYDGSISTTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIFLGYGGLE
HPINENVICNTTGCPGKTQRDCNQASHSPWFSDRRMVNSIIVVDKGLNSI
PKLKVWTISMRQNYWGSEGRLLLLGNKIYIYTRSTSWHSKLQLGIIDITD
YSDIRIKWTWHNVLSRPGNNECPWGHSCPDGCITGVYTDAYPLNPTGSIV
SSVILDSQKSRVNPVITYSTATERVNELAILNRTLSAGYTTTSCITHYNK
GYCFHIVEINHKSLNTLQPMLFKTEIPKSCS

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1v2i Chain A Residue 1001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1v2i Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): D279 S282 P283 G284 A316
• Binding residue (residue number reindexed from 1): D138 S141 P142 G143 A175
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity
• GO:0046789 host cell surface receptor binding

Biological Process

• GO:0019058 viral life cycle

Cellular Component

• GO:0019031 viral envelope

External links

• PDB: RCSB:1v2i, PDBe:1v2i, PDBj:1v2i
• PDBsum: 1v2i
• PubMed: 14729348
• UniProt: Q6WJ03