Structure of PDB 1v2e Chain A Binding Site BS01

Receptor Information
>1v2e Chain A (length=368) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRLHPRTEAAKESIFPRMSGLAQRLGAVNLGQGFPSNPPPPFLLEAVRRA
LGRQDQYAPPAGLPALREALAEEFAVEPESVVVTSGATEALYVLLQSLVG
PGDEVVVLEPFFDVYLPDAFLAGAKARLVRLDLTPEGFRLDLSALEKALT
PRTRALLLNTPMNPTGLVFGERELEAIARLARAHDLFLISDEVYDELYYG
ERPRRLREFAPERTFTVGSAGKRLEATGYRVGWIVGPKEFMPRLAGMRQW
TSFSAPTPLQAGVAEALKLARREGFYEALREGYRRRRDLLAGGLRAMGLR
VYVPEGTYFLMAELPGWDAFRLVEEARVALIPASAFYLEDPPKDLFRFAF
CKTEEELHLALERLGRVV
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain1v2e Chain A Residue 510 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1v2e Crystal structures of glutamine:phenylpyruvate aminotransferase from Thermus thermophilus HB8: induced fit and substrate recognition
Resolution2.6 Å
Binding residue
(original residue number in PDB)		G86 A87 T88 F112 D191 V193 Y194 S219 K222 R230
Binding residue
(residue number reindexed from 1)		G86 A87 T88 F112 D191 V193 Y194 S219 K222 R230
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) F112 A181 A183 K222
Catalytic site (residue number reindexed from 1) F112 A181 A183 K222
Enzyme Commision number 2.6.1.15: glutamine--pyruvate transaminase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009058 biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:1v2e, PDBe:1v2e, PDBj:1v2e
PDBsum1v2e
PubMed14761974
UniProtQ75WK2

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