Structure of PDB 1v10 Chain A Binding Site BS01

Receptor Information

>1v10 Chain A (length=487) Species: 219653 (Rigidoporus microporus)

ATVALDLHILNANLDPDGTGARSAVTAEGTTIAPLITGNIDDRFQINVID
QLTDANMRRATSIHWHGFFQAGTTEMDGPAFVNQCPIIPNESFVYDFVVP
GQAGTYWYHSHLSTQYCDGLRGAFVVYDPNDPHLSLYDVDDASTVITIAD
WYHSLSTKAPPAPDTTLINGLGRNSANPSAGQLAVVSVQSGKRYRFRIVS
TSCFPNYAFSIDGHRMTVIEVDGVSHQPLTVDSLTIFAGQRYSVVVEANQ
AVGNYWIRANPSNGRNGFTGGINSAIFRYQGAAVAEPTTSQNSGTALNEA
NLIPLINPGAPGNPVPGGADINLNLRIGRNATTADFTINGAPFIPPTVPV
LLQILSGVTNPNDLLPGGAVISLPANQVIEISIPGGGNHPFHLHGHNFDV
VRTPGSSVYNYVNPVRRDVVSIGGGGDNVTFRFVTDNPGPWFLHCHIDWH
LEAGLAVVFAEDIPNIPIANAISPAWDDLCPKYNANN

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 1v10 Chain A Residue 1500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1v10 The Structure of Rigidoporus Lignosus Laccase Containing a Full Complement of Copper Ions, Reveals an Asymmetrical Arrangement for the T3 Copper Pair
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): H66 H109 H453
• Binding residue (residue number reindexed from 1): H66 H109 H446
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H64 H66 H109 H111 H396 H399 H401 H451 C452 H453 I454 H457 L462
• Catalytic site (residue number reindexed from 1): H64 H66 H109 H111 H389 H392 H394 H444 C445 H446 I447 H450 L455
• Enzyme Commision number: 1.10.3.2: laccase.

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity

External links

• PDB: RCSB:1v10, PDBe:1v10, PDBj:1v10
• PDBsum: 1v10
• PubMed: 15364578
• UniProt: Q6H9H7