Structure of PDB 1v0t Chain A Binding Site BS01

Receptor Information
>1v0t Chain A (length=491) Species: 172564 (Streptomyces sp. PMF) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SATPHLDAVEQTLRQVSPGLEGDVWERTSGNKLDGSAADPSDWLLQTPGC
WGDDKCADRVGTKRLLAKMTENIGNATRTVDISTLAPFPNGAFQDAIVAG
LKESAAKGNKLKVRILVGAAVIPSKYRDELTAKLGKAAENITLNVASMTT
SKTAFSWNHSKILVVDGQSALTGGINSWKDDYLDTTHPVSDVDLALTGPA
AGSAGRYLDTLWTWTCQNKSNIASVWFAASGNAGCMPTMHKDTNPKASPA
TGNVPVIAVGGLGVGIKDVDPKSTFRPDLPTASDTKCVVGLHDNTNADRD
YDTVNPEESALRALVASAKGHIEISQQDLNATCPPLPRYDIRLYDALAAK
MAAGVKVRIVVSDPANRGYSQIKSLSEISDTLRNRLANITGGQQAAKTAM
CSNLQLATFRSSPNGKWADGHPYAQHHKLVSVDSSTFYIGSKNLYPSWLQ
DFGYIVESPEAAKQLDAKLLDPQWKYSQETATVDYARGICN
Ligand information
Ligand IDPO3
InChIInChI=1S/O3P/c1-4(2)3/q-3
InChIKeyAQSJGOWTSHOLKH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P-]([O-])=O
ACDLabs 10.04[O-][PH2-]([O-])=O
OpenEye OEToolkits 1.5.0[O-][P-](=O)[O-]
FormulaO3 P
NamePHOSPHITE ION
ChEMBL
DrugBank
ZINC
PDB chain1v0t Chain A Residue 1515 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1v0t The Reaction Mechanism of Phospholipase D from Streptomyces Sp. Strain Pmf. Snapshots Along the Reaction Pathway Reveal a Pentacoordinate Reaction Intermediate and an Unexpected Final Product
Resolution1.53 Å
Binding residue
(original residue number in PDB)		H170 K172 H448 K450
Binding residue
(residue number reindexed from 1)		H159 K161 H426 K428
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H170 D202 H448 D473
Catalytic site (residue number reindexed from 1) H159 D191 H426 D451
Enzyme Commision number 3.1.4.4: phospholipase D.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004630 phospholipase D activity
GO:0030572 phosphatidyltransferase activity
Biological Process
GO:0032049 cardiolipin biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1v0t, PDBe:1v0t, PDBj:1v0t
PDBsum1v0t
PubMed15165852
UniProtP84147

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