Structure of PDB 1uwv Chain A Binding Site BS01

Receptor Information
>1uwv Chain A (length=417) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QIITVSVNDLDSFGQGVARHNGKTLFIPGLLPQENAEVTVTEDKKQYARA
KVVRRLSDSPERETPRCPHFGVCGGCQQQHASVDLQQRSKSAALARLMKH
DVSEVIADVPWGYRRRARLSLNYLPKTQQLQMGFRKAGSSDIVDVKQCPI
LAPQLEALLPKVRACLGSLQAMRHLGHVELVQATSGTLMILRHTAPLSSA
DREKLERFSHSEGLDLYLAPDSEILETVSGEMPWYDSNGLRLTFSPRDFI
QVNAGVNQKMVARALEWLDVQPEDRVLDLFCGMGNFTLPLATQAASVVGV
EGVPALVEKGQQNARLNGLQNVTFYHENLEEDVTKQPWAKNGFDKVLLDP
ARAGAAGVMQQIIKLEPIRIVYVSCNPATLARDSEALLKAGYTIARLAML
DMFPHTGHLESMVLFSR
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain1uwv Chain A Residue 1432 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1uwv Crystal Structure of Ruma, an Iron-Sulfur Cluster Containing E. Coli Ribosomal RNA 5-Methyluridine Methyltransferase.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		C81 C87 G89 C90 Q93 F148 C162 P163 I164 R431
Binding residue
(residue number reindexed from 1)		C67 C73 G75 C76 Q79 F134 C148 P149 I150 R417
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.190: 23S rRNA (uracil(1939)-C(5))-methyltransferase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005506 iron ion binding
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0070041 rRNA (uridine-C5-)-methyltransferase activity
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0009451 RNA modification
GO:0031167 rRNA methylation
GO:0032259 methylation
GO:0070475 rRNA base methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1uwv, PDBe:1uwv, PDBj:1uwv
PDBsum1uwv
PubMed15016356
UniProtP55135|RLMD_ECOLI 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD (Gene Name=rlmD)

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