Structure of PDB 1uvp Chain A Binding Site BS01

Receptor Information

>1uvp Chain A (length=240) Species: 9823 (Sus scrofa)

VVGGTEAQRNSWPSQISLQYRSGSSWAHTCGGTLIRQNWVMTAAHCVDRE
LTFRVVVGEHNLNQNDGTEQYVGVQKIVVHPYWNTDDVAAGYDIALLRLA
QSVTLNSYVQLGVLPRAGTILANNSPCYITGWGLTRTNGQLAQTLQQAYL
PTVDYAICSSSSYWGSTVKNSMVCAGGDGVRSGCQGDSGGPLHCLVNGQY
AVHGVTSFVSRLGCNVTRKPTVFTRVSAYISWINNVIASN

Ligand information

• Ligand ID: CD
• InChI: InChI=1S/Cd/q+2
• InChIKey: WLZRMCYVCSSEQC-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Cd++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cd+2]
• Formula: Cd
• Name: CADMIUM ION
• PDB chain: 1uvp Chain A Residue 1240

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1uvp On the Influence of the Incident Photon Energy on the Radiation Damage in Crystalline Biological Samples
• Resolution: 1.85 Å
• Binding residue (original residue number in PDB): E59 N61 Q64 D66 E69
• Binding residue (residue number reindexed from 1): E59 N61 Q64 D66 E69
• Annotation score: 3

Enzymatic activity

• Catalytic site (original residue number in PDB): H45 D93 Q185 G186 D187 S188 G189
• Catalytic site (residue number reindexed from 1): H45 D93 Q185 G186 D187 S188 G189
• Enzyme Commision number: 3.4.21.36: pancreatic elastase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005515 protein binding
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space

External links

• PDB: RCSB:1uvp, PDBe:1uvp, PDBj:1uvp
• PDBsum: 1uvp
• PubMed: 15840915
• UniProt: P00772|CELA1_PIG Chymotrypsin-like elastase family member 1 (Gene Name=CELA1)