Structure of PDB 1uu1 Chain A Binding Site BS01

Receptor Information
>1uu1 Chain A (length=329) Species: 2336 (Thermotoga maritima) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LIAKRAYPYETEKRDKTYLALNENPFPFPEDLVDEVFRRLNSDALRIYYD
SPDEELIEKILSYLDTDFLSKNNVSVGNGADEIIYVMMLMFDRSVFFPPT
YSCYRIFAKAVGAKFLEVPLTKDLRIPEVNVGEGDVVFIPNPNNPTGHVF
EREEIERILKTGAFVALDEAYYEFHGESYVDFLKKYENLAVIRTFSKAFS
LAAQRVGYVVASEKFIDAYNRVRLPFNVSYVSQMFAKVALDHREIFEERT
KFIVEERERMKSALREMGYRITDSRGNFVFVFMEKEEKERLLEHLRTKNV
AVRSFREGVRITIGKREENDMILRELEVF
Ligand information
Ligand IDPMP
InChIInChI=1S/C8H13N2O5P/c1-5-8(11)7(2-9)6(3-10-5)4-15-16(12,13)14/h3,11H,2,4,9H2,1H3,(H2,12,13,14)
InChIKeyZMJGSOSNSPKHNH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1CN)C
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)CN)O
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(CN)c1O
FormulaC8 H13 N2 O5 P
Name4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE;
PYRIDOXAMINE-5'-PHOSPHATE
ChEMBLCHEMBL1235353
DrugBankDB02142
ZINCZINC000001532708
PDB chain1uu1 Chain A Residue 1335 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1uu1 Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-Phosphate Aminotransferase
Resolution2.38 Å
Binding residue
(original residue number in PDB)		G84 A85 D86 Y106 N149 D173 A175 Y176 T199 S201 K202 R210
Binding residue
(residue number reindexed from 1)		G79 A80 D81 Y101 N144 D168 A170 Y171 T194 S196 K197 R205
Annotation score1
Enzymatic activity
Enzyme Commision number 2.6.1.9: histidinol-phosphate transaminase.
Gene Ontology
Molecular Function
GO:0004400 histidinol-phosphate transaminase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000105 L-histidine biosynthetic process
GO:0009058 biosynthetic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:1uu1, PDBe:1uu1, PDBj:1uu1
PDBsum1uu1
PubMed15007066
UniProtQ9X0D0|HIS8_THEMA Histidinol-phosphate aminotransferase (Gene Name=hisC)

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