Structure of PDB 1uu0 Chain A Binding Site BS01

Receptor Information
>1uu0 Chain A (length=328) Species: 2336 (Thermotoga maritima) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IAKRAYPYETEKRDKTYLALNENPFPFPEDLVDEVFRRLNSDALRIYYDS
PDEELIEKILSYLDTDFLSKNNVSVGNGADEIIYVMMLMFDRSVFFPPTY
SCYRIFAKAVGAKFLEVPLTKDLRIPEVNVGEGDVVFIPNPNNPTGHVFE
REEIERILKTGAFVALDEAYYEFHGESYVDFLKKYENLAVIRTFSKAFSL
AAQRVGYVVASEKFIDAYNRVRLPFNVSYVSQMFAKVALDHREIFEERTK
FIVEERERMKSALREMGYRITDSRGNFVFVFMEKEEKERLLEHLRTKNVA
VRSFREGVRITIGKREENDMILRELEVF
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain1uu0 Chain A Residue 1336 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1uu0 Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-Phosphate Aminotransferase
Resolution2.85 Å
Binding residue
(original residue number in PDB)		G84 A85 D86 T199 S201 R210
Binding residue
(residue number reindexed from 1)		G78 A79 D80 T193 S195 R204
Annotation score1
Enzymatic activity
Enzyme Commision number 2.6.1.9: histidinol-phosphate transaminase.
Gene Ontology
Molecular Function
GO:0004400 histidinol-phosphate transaminase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000105 L-histidine biosynthetic process
GO:0009058 biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1uu0, PDBe:1uu0, PDBj:1uu0
PDBsum1uu0
PubMed15007066
UniProtQ9X0D0|HIS8_THEMA Histidinol-phosphate aminotransferase (Gene Name=hisC)

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