Structure of PDB 1ukh Chain A Binding Site BS01
Receptor Information
>1ukh Chain A (length=321) Species:
9606
(Homo sapiens) [
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NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLS
RPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVM
ELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV
VKSDCTLKILDFGLYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLF
PGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLF
PDVLFPNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEA
EAPPPKIEEWKELIYKEVMDL
Ligand information
>1ukh Chain B (length=10) Species:
10090
(Mus musculus) [
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PKRPTTLNLF
Receptor-Ligand Complex Structure
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PDB
1ukh
Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
Resolution
2.35 Å
Binding residue
(original residue number in PDB)
V118 E126 R127 Y130 S161 D162 C163 W324 E329
Binding residue
(residue number reindexed from 1)
V110 E118 R119 Y122 S153 D154 C155 W294 E299
Enzymatic activity
Catalytic site (original residue number in PDB)
D151 K153 N156 D169
Catalytic site (residue number reindexed from 1)
D143 K145 N148 D161
Enzyme Commision number
2.7.11.24
: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672
protein kinase activity
GO:0004707
MAP kinase activity
GO:0005524
ATP binding
Biological Process
GO:0006468
protein phosphorylation
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Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:1ukh
,
PDBe:1ukh
,
PDBj:1ukh
PDBsum
1ukh
PubMed
15141161
UniProt
P45983
|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)
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