Structure of PDB 1ukh Chain A Binding Site BS01

Receptor Information
>1ukh Chain A (length=321) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLS
RPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVM
ELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV
VKSDCTLKILDFGLYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLF
PGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLF
PDVLFPNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEA
EAPPPKIEEWKELIYKEVMDL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1ukh Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
Resolution2.35 Å
Binding residue
(original residue number in PDB)
V118 E126 R127 Y130 S161 D162 C163 W324 E329
Binding residue
(residue number reindexed from 1)
V110 E118 R119 Y122 S153 D154 C155 W294 E299
Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169
Catalytic site (residue number reindexed from 1) D143 K145 N148 D161
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function

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Biological Process
External links
PDB RCSB:1ukh, PDBe:1ukh, PDBj:1ukh
PDBsum1ukh
PubMed15141161
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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