Structure of PDB 1udh Chain A Binding Site BS01

Receptor Information
>1udh Chain A (length=228) Species: 10299 (Human alphaherpesvirus 1 strain 17) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDWTTFRRVFLIDDAWRPLMEPELANPLTAHLLAEYNRRCQTEEVLPPRE
DVFSWTRYCTPDEVRVVIIGQDPYHHPGQAHGLAFSVRANVPPPPSLRNV
LAAVKNCYPEARMSGHGCLEKWARDGVLLLNTTLTVKRGAAASHSRIGWD
RFVGGVIRRLAARRPGLVFMLWGTHAQNAIRPDPRVHCVLKFSHPSPLSK
VPFGTCQHFLVANRYLETRSISPIDWSV
Ligand information
Ligand IDURA
InChIInChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
InChIKeyISAKRJDGNUQOIC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O=C1NC=CC(=O)N1
ACDLabs 10.04O=C1C=CNC(=O)N1
OpenEye OEToolkits 1.5.0C1=CNC(=O)NC1=O
FormulaC4 H4 N2 O2
NameURACIL
ChEMBLCHEMBL566
DrugBankDB03419
ZINCZINC000000895045
PDB chain1udh Chain A Residue 247 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1udh The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		G86 D88 Y90 A100 F101 N147
Binding residue
(residue number reindexed from 1)		G70 D72 Y74 A84 F85 N131
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D88 Y90 F101 H210
Catalytic site (residue number reindexed from 1) D72 Y74 F85 H194
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0004844 uracil DNA N-glycosylase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:1udh, PDBe:1udh, PDBj:1udh
PDBsum1udh
PubMed7845459
UniProtP10186|UNG_HHV11 Uracil-DNA glycosylase (Gene Name=UL2)

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