Structure of PDB 1uca Chain A Binding Site BS01

Receptor Information
>1uca Chain A (length=190) Species: 3673 (Momordica charantia) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FDSFWFVQQWPPAVCSFQKSGSCPGSGLRTFTIHGLWPQQSGTSLTNCPG
SPFDITKISHLQSQLNTLWPNVLRANNQQFWSHEWTKHGTCSESTFNQAA
YFKLAVDMRNNYDIIGALRPHAAGPNGRTKSRQAIKGFLKAKFGKFPGLR
CRTDPQTKVSYLVQVVACFAQDGSTLIDCTRDTCGANFIF
Ligand information
Ligand IDU2P
InChIInChI=1S/C9H13N2O9P/c12-3-4-6(14)7(20-21(16,17)18)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyHQIDPEYTETUCNF-XVFCMESISA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C1NC(=O)N(C=C1)C2OC(C(O)C2OP(=O)(O)O)CO
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)OP(=O)(O)O
CACTVS 3.341OC[CH]1O[CH]([CH](O[P](O)(O)=O)[CH]1O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OP(=O)(O)O
CACTVS 3.341OC[C@H]1O[C@H]([C@H](O[P](O)(O)=O)[C@@H]1O)N2C=CC(=O)NC2=O
FormulaC9 H13 N2 O9 P
NamePHOSPHORIC ACID MONO-[2-(2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-YL] ESTER;
URIDINE-2'-PHOSPHATE;
2'-URIDINEMONOPHOSPHATE
ChEMBLCHEMBL447360
DrugBank
ZINCZINC000004095997
PDB chain1uca Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1uca Crystal structures of the ribonuclease MC1 from bitter gourd seeds, complexed with 2'-UMP or 3'-UMP, reveal structural basis for uridine specificity
Resolution1.48 Å
Binding residue
(original residue number in PDB)		Q9 N71 V72 L73 F80 H83 K87
Binding residue
(residue number reindexed from 1)		Q9 N71 V72 L73 F80 H83 K87
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H34 W37 S44 E84 K87 H88
Catalytic site (residue number reindexed from 1) H34 W37 S44 E84 K87 H88
Enzyme Commision number 4.6.1.19: ribonuclease T2.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0016829 lyase activity
GO:0033897 ribonuclease T2 activity
Biological Process
GO:0006401 RNA catabolic process
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1uca, PDBe:1uca, PDBj:1uca
PDBsum1uca
PubMed10964705
UniProtP23540|RNMC1_MOMCH Ribonuclease MC (Gene Name=MC1)

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