Structure of PDB 1u7c Chain A Binding Site BS01

Receptor Information

>1u7c Chain A (length=383) Species: 562 (Escherichia coli)

AVADKADNAFMMICTALVLFMTIPGIALFYGGLIRGKNVLSMLTQVTVTF
ALVCILWVVYGYSLASGEGNNFFGNINWLMLKNIELTAVMGSIYQYIHVA
FQGSFACITVGLIVGALAERIRFPAVLIFVVVWLTLSYIPIAHMVWGGGL
LASHGALDFAGGTVVHINAAIAGLVGAYLIGKRVGFGKEAFKPHNLPMVF
TGTAILYIGWFGFNAGSAGTANEIAALAFVNTVVATAAAILGWIFGEWAL
RGLPSLLGACSGAIAGLVGVTPACGYIGVGGALIIGVVAGLAGLWGVTML
KRLLRVDDPCDVFGVHGVCGIVGCIMTGIFAASSLGGVGFAEGVTMGHQL
LVQLESIAITIVWSGVVAFIGYKLADLTVGLRV

Ligand information

• Ligand ID: NME
• InChI: InChI=1S/CH5N/c1-2/h2H2,1H3
• InChIKey: BAVYZALUXZFZLV-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.370
  OpenEye OEToolkits 1.7.0: CN
  ACDLabs 12.01: NC
• Formula: C H5 N
• Name: METHYLAMINE
• ChEMBL: CHEMBL43280
• DrugBank: DB01828
• PDB chain: 1u7c Chain A Residue 400

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1u7c Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A
• Resolution: 1.85 Å
• Binding residue (original residue number in PDB): F107 W148
• Binding residue (residue number reindexed from 1): F105 W146
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008519 ammonium channel activity
• GO:0042802 identical protein binding

Biological Process

• GO:0015670 carbon dioxide transport
• GO:0072488 ammonium transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:1u7c, PDBe:1u7c, PDBj:1u7c
• PDBsum: 1u7c
• PubMed: 15361618
• UniProt: P69681|AMTB_ECOLI Ammonium transporter AmtB (Gene Name=amtB)