Structure of PDB 1u1d Chain A Binding Site BS01

Receptor Information
>1u1d Chain A (length=253) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSKSDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPVKLASHREF
TTWRAELDGKPVIVCSTGIGGPSTSIAVEELAQLGIRTFLRIGTTGAIQP
HINVGDVLVTTASVRLDGASLHFAPLEFPAVADFECTTALVEAAKSIGAT
THVGVTASSDTFYPGQERYDTYSGRVVRHFKGSMEEWQAMGVMNYEMESA
TLLTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESHAVKIVVEAAR
RLL
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain1u1d Chain A Residue 3401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1u1d Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.
Resolution2.001 Å
Binding residue
(original residue number in PDB)		G26 R30 R91 G93 T94
Binding residue
(residue number reindexed from 1)		G26 R30 R91 G93 T94
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H8 G26 R30 R48 E80 R91 T94 R168 I220 V221 R223 M234
Catalytic site (residue number reindexed from 1) H8 G26 R30 R48 E80 R91 T94 R168 I220 V221 R223 M234
Enzyme Commision number 2.4.2.3: uridine phosphorylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004850 uridine phosphorylase activity
GO:0005524 ATP binding
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0030955 potassium ion binding
GO:0042802 identical protein binding
GO:0047847 deoxyuridine phosphorylase activity
Biological Process
GO:0006218 uridine catabolic process
GO:0006974 DNA damage response
GO:0009116 nucleoside metabolic process
GO:0009164 nucleoside catabolic process
GO:0009166 nucleotide catabolic process
GO:0044206 UMP salvage
GO:0046050 UMP catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1u1d, PDBe:1u1d, PDBj:1u1d
PDBsum1u1d
PubMed15983408
UniProtP12758|UDP_ECOLI Uridine phosphorylase (Gene Name=udp)

[Back to BioLiP]