Structure of PDB 1u10 Chain A Binding Site BS01

Receptor Information
>1u10 Chain A (length=232) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATPWQKITQPVPGSAQSIGSFSNGCIVGADTLPIQSEHYQVMRTDQRRYF
GHPDLVMFIQRLSSQVSNLGMGTVLIGDMGMPAGGRGHASHQTGLDVDIF
LQLPKTRWTSAQLLRPQALDLVSRDGKHVVSTLWKPEIFSLIKLAAQDKD
VTRIFVNPAIKQQLCLDAGTDRDWLRKVRPWFQHRAHMHVRLRCPADSLE
CEDQPLPPSGDGCGAELQSWFELPPSCQALLD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1u10 Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1u10 Peptidoglycan amidase MepA is a LAS metallopeptidase
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H110 H113 D120 H211
Binding residue
(residue number reindexed from 1)		H88 H91 D98 H189
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0000270 peptidoglycan metabolic process
GO:0006508 proteolysis
GO:0009252 peptidoglycan biosynthetic process
GO:0009410 response to xenobiotic stimulus
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1u10, PDBe:1u10, PDBj:1u10
PDBsum1u10
PubMed15292190
UniProtP0C0T5|MEPA_ECOLI Penicillin-insensitive murein endopeptidase (Gene Name=mepA)

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