Structure of PDB 1tzs Chain A Binding Site BS01

Receptor Information

>1tzs Chain A (length=322) Species: 9606 (Homo sapiens)

KEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKT
HSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFG
ESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFS
VYMSSNPGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGT
VMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLN
VMPDVTFTINGVPYTLSPTAYTLLDQFCSSGFQGLDIHPPAGPLWILGDV
FIRQFYSVFDRGNNRVGLAPAV

Ligand information

>1tzs Chain P (length=9) Species: 9606 (Homo sapiens)

GSLHRVPLR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1tzs Crystal structure of an activation intermediate of cathepsin e
• Resolution: 2.35 Å
• Binding residue (original residue number in PDB): Y25 F26 F42 E103 L105 D158 S176 E177 L178 I179 F180 D184
• Binding residue (residue number reindexed from 1): Y12 F13 F29 E90 L92 D145 S161 E162 L163 I164 F165 D169

Enzymatic activity

• Catalytic site (original residue number in PDB): D43 S46 N48 W50 Y86 D228 T231
• Catalytic site (residue number reindexed from 1): D30 S33 N35 W37 Y73 D213 T216
• Enzyme Commision number: 3.4.23.34: cathepsin E.

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity
• GO:0008233 peptidase activity
• GO:0042802 identical protein binding

Biological Process

• GO:0006508 proteolysis
• GO:0016540 protein autoprocessing
• GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

• GO:0005768 endosome
• GO:0043231 intracellular membrane-bounded organelle

External links

• PDB: RCSB:1tzs, PDBe:1tzs, PDBj:1tzs
• PDBsum: 1tzs
• PubMed: 15342244
• UniProt: P14091|CATE_HUMAN Cathepsin E (Gene Name=CTSE)