Structure of PDB 1txu Chain A Binding Site BS01

Receptor Information
>1txu Chain A (length=254) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETDRVSKEFIEFLKTFHKTGQEIYKQTKLFLEGMHYKRDLSIEEQSECAQ
DFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEK
KDLAIQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRV
PRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGNPPRLQS
NIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDR
YMSG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1txu Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1txu Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5
Resolution2.35 Å
Binding residue
(original residue number in PDB)		D274 H297
Binding residue
(residue number reindexed from 1)		D141 H164
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0016192 vesicle-mediated transport

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Molecular Function
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Biological Process
External links
PDB RCSB:1txu, PDBe:1txu, PDBj:1txu
PDBsum1txu
PubMed15339665
UniProtQ9UJ41|RABX5_HUMAN Rab5 GDP/GTP exchange factor (Gene Name=RABGEF1)

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