Structure of PDB 1tlz Chain A Binding Site BS01

Receptor Information
>1tlz Chain A (length=251) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSDWWHQSVNVVGSYHTRFGPQIRNDTYLEYEAFAKKDWFDFYGYADAPV
PLFMEIEPRFSIDKLTNTDLSFGPFKEWYFANNYIYDMGRNKDGRQSTWY
MGLGTDIDTGLPMSLSMNVYAKYQWQNYGAANENEWDGYRFKIKYFVPIT
DLWGGQLSYIGFTNFDWGSDLGDDSGNAINGIKTRTNNSIASSHILALNY
DHWHYSVVARYWHDGGQWNDDAELNFGNGNFNVRSTGWGGYLVVGYNFHH
H
Ligand information
Ligand IDURI
InChIInChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChIKeyDRTQHJPVMGBUCF-XVFCMESISA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC[CH]1O[CH]([CH](O)[CH]1O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
ACDLabs 10.04O=C1NC(=O)N(C=C1)C2OC(C(O)C2O)CO
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
CACTVS 3.341OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
FormulaC9 H12 N2 O6
NameURIDINE
ChEMBLCHEMBL100259
DrugBankDB02745
ZINCZINC000002583633
PDB chain1tlz Chain A Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1tlz Crystal structure of the bacterial nucleoside transporter Tsx.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		F27 Y36 Y53 D55 F77
Binding residue
(residue number reindexed from 1)		F19 Y28 Y45 D47 F53
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005337 nucleoside transmembrane transporter activity
GO:0015288 porin activity
GO:0015471 nucleoside-specific channel forming porin activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0015858 nucleoside transport
GO:0046718 symbiont entry into host cell
GO:0055085 transmembrane transport
GO:1901642 nucleoside transmembrane transport
Cellular Component
GO:0009279 cell outer membrane
GO:0046930 pore complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1tlz, PDBe:1tlz, PDBj:1tlz
PDBsum1tlz
PubMed15272310
UniProtP0A927|TSX_ECOLI Nucleoside-specific channel-forming protein Tsx (Gene Name=tsx)

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