Structure of PDB 1tfm Chain A Binding Site BS01

Receptor Information
>1tfm Chain A (length=240) Species: 3972 (Viscum album) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YERLDLDVTSQTTGEEYFRFITLLRDYVSSGSFSNEIPLLRQSGGGVEAA
RFVLVELTNEGGDSITAAIDVTNLYVVAYQAGSQSYFLSGPGTHLFTGTT
RSSLPFNGSYPDLEQYAGHRKQIPLGIDQLIQSVTALRFPGNTRTQARSI
LILIQMISEAARFNPILWRARQYINSGASFLPDVYMLELETSWGQQSTQV
QQSTEGVFNNPIRLAIPGNFVTLTNVRDVIASLAIMLFVC
Ligand information
Ligand IDP6C
InChIInChI=1S/C10H11N5O2/c1-4(2)6-7-8(15-10(11)14-6)12-3-5(13-7)9(16)17/h3-4H,1-2H3,(H,16,17)(H2,11,12,14,15)
InChIKeyGPHPGFBRJYCUDO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)c1nc2c(nc1)nc(nc2C(C)C)N
CACTVS 3.341CC(C)c1nc(N)nc2ncc(nc12)C(O)=O
OpenEye OEToolkits 1.5.0CC(C)c1c2c(ncc(n2)C(=O)O)nc(n1)N
FormulaC10 H11 N5 O2
Name2-AMINO-4-ISOPROPYL-PTERIDINE-6-CARBOXYLIC ACID
ChEMBL
DrugBank
ZINCZINC000005963371
PDB chain1tfm Chain A Residue 242 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1tfm CRYSTAL STRUCTURE OF A RIBOSOME INACTIVATING PROTEIN IN ITS NATURALLY INHIBITED FORM
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Y75 S109 Y110 R162
Binding residue
(residue number reindexed from 1)		Y75 S109 Y110 R162
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) V76 E159 R162
Catalytic site (residue number reindexed from 1) V76 E159 R162
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:1tfm, PDBe:1tfm, PDBj:1tfm
PDBsum1tfm
PubMed
UniProtQ6ITZ3|ML4_VISAL Beta-galactoside-specific lectin 4

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