Structure of PDB 1tdz Chain A Binding Site BS01

Receptor Information
>1tdz Chain A (length=265) Species: 1358 (Lactococcus lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELPEVETVRRELEKRIVGQKIISIEATYPRMVLTGFEQLKKELTGKTIQG
ISRRGKYLIFEIGDDFRLISHLRMEGKYRLATLDAPREKHDHLTMKFADG
QLIYADVRKFGTWELISTDQVLPYFLKKKIGPEPTYEDFDEKLFREKLRK
STKKIKPYLLEQTLVAGLGNIYVDEVLWLAKIHPEKETNQLIESSIHLLH
DSIIEILQKAIKLGGSSILGSTGKMQNELQVYGKTGEKCSRCGAEIQKIK
VAGRGTHFCPVCQQK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1tdz Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5-formamidopyrimidine) by formamidopyrimidine-DNA glycosylase
Resolution1.8 Å
Binding residue
(original residue number in PDB)		E2 E5 K57 H72 R74 M75 K129 G170 N171 I172 S217 I219 Y238 K254 K256 R260
Binding residue
(residue number reindexed from 1)		E1 E4 K56 H71 R73 M74 K128 G169 N170 I171 S216 I218 Y232 K248 K250 R254
Binding affinityPDBbind-CN: Kd=3nM
Enzymatic activity
Enzyme Commision number 3.2.2.23: DNA-formamidopyrimidine glycosylase.
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016829 lyase activity
GO:0019104 DNA N-glycosylase activity
GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0046872 metal ion binding
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1tdz, PDBe:1tdz, PDBj:1tdz
PDBsum1tdz
PubMed15249553
UniProtP42371|FPG_LACLC Formamidopyrimidine-DNA glycosylase (Gene Name=mutM)

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