Structure of PDB 1tc2 Chain A Binding Site BS01

Receptor Information
>1tc2 Chain A (length=186) Species: 5693 (Trypanosoma cruzi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLKGS
FMFTADLCRALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHSIEG
HHVLIVEDIVDTALTLNYLYHMYFTRRPASLKTVVLLDKREGRRVPFSAD
YVVANIPNAFVIGYGLDYDDTYRELRDIVVLRPEVY
Ligand information
Ligand ID7HP
InChIInChI=1S/C5H4N4O/c10-5-4-3(1-8-9-4)6-2-7-5/h1-2H,(H,8,9)(H,6,7,10)
InChIKeyJFZSDNLQDTYVEE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04n1c(O)c2c(nc1)cnn2
CACTVS 3.341Oc1ncnc2cn[nH]c12
OpenEye OEToolkits 1.5.0c1c2c(c(ncn2)O)[nH]n1
FormulaC5 H4 N4 O
Name7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE
ChEMBL
DrugBank
ZINCZINC000011592630
PDB chain1tc2 Chain A Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1tc2 Approaching the transition state in the crystal structure of a phosphoribosyltransferase.
Resolution1.81 Å
Binding residue
(original residue number in PDB)		K143 F164 V165
Binding residue
(residue number reindexed from 1)		K139 F160 V161
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1tc2, PDBe:1tc2, PDBj:1tc2
PDBsum1tc2
PubMed9860824
UniProtQ4DRC4

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