Structure of PDB 1t8h Chain A Binding Site BS01

Receptor Information
>1t8h Chain A (length=272) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPDIFQQEARGWLRCGAPPFAGAVAGLTTKHGGESKGPFASLNMGLHVGD
DRTDVVNNRRRLAEWLAFPLERWVCCEQVHGADIQKVTKSDRGNGAQDFA
TAVPGVDGLYTDEAGVLLALCFADCVPIYFVAPSAGLVGLAHAGWRGTAG
GIAGHMVWLWQTREHIAPSDIYVAIGPAIGPCCYTVDDRVVDSLRPTLPP
ESPLPWRETSPGQYALDLKEANRLQLLAAGVPNSHIYVSERCTSCEEALF
FSHRRDRGTTGRMLAFIGRREE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1t8h Chain A Residue 275 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1t8h 1.8 A CRYSTAL STRUCTURE OF AN UNCHARACTERIZED B. STEAROTHERMOPHILUS PROTEIN
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C182 C183 C242 C245
Binding residue
(residue number reindexed from 1)		C182 C183 C242 C245
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.1: purine-nucleoside phosphorylase.
2.4.2.28: S-methyl-5'-thioadenosine phosphorylase.
3.5.4.4: adenosine deaminase.
Gene Ontology
Molecular Function
GO:0004000 adenosine deaminase activity
GO:0004731 purine-nucleoside phosphorylase activity
GO:0005507 copper ion binding
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0017061 S-methyl-5-thioadenosine phosphorylase activity
GO:0046872 metal ion binding
GO:0046936 2'-deoxyadenosine deaminase activity

View graph for
Molecular Function
External links
PDB RCSB:1t8h, PDBe:1t8h, PDBj:1t8h
PDBsum1t8h
PubMed
UniProtP84138|PURNU_GEOS3 Purine nucleoside phosphorylase YlmD (Gene Name=ylmD)

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