Structure of PDB 1t3n Chain A Binding Site BS01

Receptor Information
>1t3n Chain A (length=388) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVK
KLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFD
ENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVG
SQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESC
QHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS
VAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLA
SLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGN
YDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1t3n Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		K207 P240 G241 I242 G243 K245 T246 S359 R360 Q361 C362 P363
Binding residue
(residue number reindexed from 1)		K181 P214 G215 I216 G217 K219 T220 S333 R334 Q335 C336 P337
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1t3n, PDBe:1t3n, PDBj:1t3n
PDBsum1t3n
PubMed15254543
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

[Back to BioLiP]