Structure of PDB 1t3k Chain A Binding Site BS01

Receptor Information
>1t3k Chain A (length=132) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAMARSISYITSTQLLPLHRRPNIAIIDVRDEERNYDGHIAGSLHYASGS
FDDKISHLVQNVKDKDTLVFHSALSQVRGPTCARRLVNYLDEKKEDTGIK
NIMILERGFNGWEASGKPVCRCAEVPCKGDCA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1t3k Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1t3k A small CDC25 dual-specificity tyrosine-phosphatase isoform in Arabidopsis thaliana.
ResolutionN/A
Binding residue
(original residue number in PDB)		H39 C120 C122 C127
Binding residue
(residue number reindexed from 1)		H39 C120 C122 C127
Annotation score1
Enzymatic activity
Enzyme Commision number 1.20.4.1: arsenate reductase (glutathione/glutaredoxin).
3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008794 arsenate reductase (glutaredoxin) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0046685 response to arsenic-containing substance
GO:0051238 sequestering of metal ion
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0009507 chloroplast

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1t3k, PDBe:1t3k, PDBj:1t3k
PDBsum1t3k
PubMed15329414
UniProtQ8GY31|CDC25_ARATH Dual specificity phosphatase Cdc25 (Gene Name=CDC25)

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