Structure of PDB 1t37 Chain A Binding Site BS01

Receptor Information
>1t37 Chain A (length=119) Species: 195058 (Naja sagittifera) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLYQFKNMIQCTVPSRSWADFADYGCYCGKGGSGTPVDDLDRCCQTHDNC
YNEAENISGCRPYFKTYSYECTQGTLTCKGDNNACAASVCDCDRLAAICF
AGAPYNDDNYNIDLKARCN
Ligand information
Receptor-Ligand Complex Structure
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PDB1t37 Crystal structure of the complex of group I PLA2 with a group II-specific peptide Leu-Ala-Ile-Tyr-Ser (LAIYS) at 2.6 A resolution.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		L2 K6 W19 A23 G30 H48 Y52 Y64
Binding residue
(residue number reindexed from 1)		L2 K6 W18 A22 G29 H47 Y51 Y63
Enzymatic activity
Catalytic site (original residue number in PDB) Y28 G30 G32 H48 D49 Y52 Y68 D94
Catalytic site (residue number reindexed from 1) Y27 G29 G31 H47 D48 Y51 Y67 D93
Enzyme Commision number 3.1.1.4: phospholipase A2.
Gene Ontology
Molecular Function
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047498 calcium-dependent phospholipase A2 activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0016042 lipid catabolic process
GO:0050482 arachidonate secretion
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:1t37, PDBe:1t37, PDBj:1t37
PDBsum1t37
PubMed16278156
UniProtP60045|PA2A3_NAJSG Acidic phospholipase A2 3 (Fragment)

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