Structure of PDB 1t34 Chain A Binding Site BS01

Receptor Information
>1t34 Chain A (length=426) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVL
GSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHW
RVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQA
LVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLL
RAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKS
AQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLL
ADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQ
RMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQE
LMAVSEHKLYWPLGYPPPDVPKCGFD
Ligand information
>1t34 Chain H (length=21) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CFGGRIDRIGAQSGLGCNSFR
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1t34 Crystal structure of hormone-bound atrial natriuretic peptide receptor extracellular domain: rotation mechanism for transmembrane signal transduction
Resolution2.95 Å
Binding residue
(original residue number in PDB)		Y88 A91 V116 E119 Y154 L158 F165 E169 Y172 M173 H185
Binding residue
(residue number reindexed from 1)		Y88 A91 V116 E119 Y154 L158 F165 E169 Y172 M173 H185
Enzymatic activity
Enzyme Commision number 4.6.1.2: guanylate cyclase.
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:1t34, PDBe:1t34, PDBj:1t34
PDBsum1t34
PubMed15117952
UniProtP18910|ANPRA_RAT Atrial natriuretic peptide receptor 1 (Gene Name=Npr1)

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