Structure of PDB 1t0i Chain A Binding Site BS01

Receptor Information

>1t0i Chain A (length=185) Species: 4932 (Saccharomyces cerevisiae)

MKVGIIMGSVRAKRVCPEIAAYVKRTIENSEELIDQKLKIQVVDLQQIAL
PLYEDDDELIPAQIKSVDEYADSKTRSWSRIVNALDIIVFVTPQYNWGYP
AALKNAIDRLYHEWHGKPALVVSYGGHGGSKCNDQLQEVLHGLKMNVIGG
VAVKIPVGTIPLPEDIVPQLSVHNEEILQLLASCI

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1t0i Chain A Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1t0i Crystal Structure and Functional Characterization of Yeast YLR011wp, an Enzyme with NAD(P)H-FMN and Ferric Iron Reductase Activities
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): D134 E138
• Binding residue (residue number reindexed from 1): D134 E138
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.5.1.39: FMN reductase [NAD(P)H].

Gene Ontology

Molecular Function

• GO:0003955 NAD(P)H dehydrogenase (quinone) activity
• GO:0008752 FMN reductase (NAD(P)H) activity
• GO:0010181 FMN binding
• GO:0016491 oxidoreductase activity
• GO:0052873 FMN reductase (NADPH) activity
• GO:0052874 FMN reductase (NADH) activity

Biological Process

• GO:0006915 apoptotic process
• GO:0034599 cellular response to oxidative stress

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:1t0i, PDBe:1t0i, PDBj:1t0i
• PDBsum: 1t0i
• PubMed: 15184374
• UniProt: Q07923|LOT6_YEAST NAD(P)H-dependent FMN reductase LOT6 (Gene Name=LOT6)