Structure of PDB 1t08 Chain A Binding Site BS01

Receptor Information
>1t08 Chain A (length=510) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMV
SAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLG
SPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLA
ITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLK
VLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQ
EGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIE
ALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVV
KLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQ
DTQRQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLY
SPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATY
AAAVLFRMSE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1t08 Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
Resolution2.1 Å
Binding residue
(original residue number in PDB)		Y306 G307 K312 K345 V349 W383 R386 N387 D390 N426 C429 N430 K435 P463 R469 H470
Binding residue
(residue number reindexed from 1)		Y161 G162 K167 K200 V204 W238 R241 N242 D245 N281 C284 N285 K290 P318 R324 H325
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0045296 cadherin binding
Biological Process
GO:0007155 cell adhesion

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:1t08, PDBe:1t08, PDBj:1t08
PDBsum1t08
PubMed15327768
UniProtP35222|CTNB1_HUMAN Catenin beta-1 (Gene Name=CTNNB1)

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