Structure of PDB 1syq Chain A Binding Site BS01

Receptor Information
>1syq Chain A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQA
AVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDP
YSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAE
VVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVK
ELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQ
LTSWDEDAW
Ligand information
>1syq Chain B (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PLLQAAKGLAGAVSELLRSAQPASA
Receptor-Ligand Complex Structure
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PDB1syq Structural basis for amplifying vinculin activation by talin
Resolution2.42 Å
Binding residue
(original residue number in PDB)		I12 Q19 M26 K35 P38 L40 V47 L54 V57 I115 F126
Binding residue
(residue number reindexed from 1)		I13 Q20 M27 K36 P39 L41 V48 L55 V58 I116 F127
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0051015 actin filament binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0015629 actin cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1syq, PDBe:1syq, PDBj:1syq
PDBsum1syq
PubMed15070891
UniProtP18206|VINC_HUMAN Vinculin (Gene Name=VCL)

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