Structure of PDB 1sxa Chain A Binding Site BS01

Receptor Information
>1sxa Chain A (length=151) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATKAVCVLKGDGPVQGTIHFEAKGDTVVVTGSITGLTEGDHGFHVHQFGD
NTQGCTSAGPHFNPLSKKHGGPKDEERHVGDLGNVTADKNGVAIVDIVDP
LISLSGEYSIIGRTMVVHEKPDDLGRGGNEESTKTGNAGSRLACGVIGIA
K
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain1sxa Chain A Residue 152 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1sxa Crystal structure of reduced bovine erythrocyte superoxide dismutase at 1.9 A resolution.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		H44 H46 H61 H118
Binding residue
(residue number reindexed from 1)		H44 H46 H61 H118
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H44 H46 H61 H69 H78 D81 H118 R141
Catalytic site (residue number reindexed from 1) H44 H46 H61 H69 H78 D81 H118 R141
Enzyme Commision number 1.15.1.1: superoxide dismutase.
Gene Ontology
Molecular Function
GO:0004784 superoxide dismutase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0030346 protein phosphatase 2B binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0000303 response to superoxide
GO:0001541 ovarian follicle development
GO:0001819 positive regulation of cytokine production
GO:0001895 retina homeostasis
GO:0002262 myeloid cell homeostasis
GO:0006749 glutathione metabolic process
GO:0006801 superoxide metabolic process
GO:0006879 intracellular iron ion homeostasis
GO:0007283 spermatogenesis
GO:0007566 embryo implantation
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0008217 regulation of blood pressure
GO:0009408 response to heat
GO:0019226 transmission of nerve impulse
GO:0019430 removal of superoxide radicals
GO:0032287 peripheral nervous system myelin maintenance
GO:0040014 regulation of multicellular organism growth
GO:0042542 response to hydrogen peroxide
GO:0043085 positive regulation of catalytic activity
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0045471 response to ethanol
GO:0046716 muscle cell cellular homeostasis
GO:0048678 response to axon injury
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051881 regulation of mitochondrial membrane potential
GO:0060047 heart contraction
GO:0060052 neurofilament cytoskeleton organization
GO:0060087 relaxation of vascular associated smooth muscle
GO:0060088 auditory receptor cell stereocilium organization
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0032839 dendrite cytoplasm
GO:0032991 protein-containing complex
GO:0043025 neuronal cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1sxa, PDBe:1sxa, PDBj:1sxa
PDBsum1sxa
PubMed7643403
UniProtP00442|SODC_BOVIN Superoxide dismutase [Cu-Zn] (Gene Name=SOD1)

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