Structure of PDB 1sp9 Chain A Binding Site BS01

Receptor Information

>1sp9 Chain A (length=362) Species: 3702 (Arabidopsis thaliana)

VRKNPKSDKFKVKRFHHIEFWCGDATNVARRFSWGLGMRFSAKSDLSTGN
MVHASYLLTSGDLRFLFTAPYSPSTASIPSFDHGSCRSFFSSHGLGVRAV
AIEVEDAESAFSISVANGAIPSSPPIVLNEAVTIAEVKLYGDVVLRYVSY
KFLPGFERVEPLDYGIRRLDHAVGNVPELGPALTYVAGFTGFHQFASGLN
SAVLASNDEMVLLPINEPVHGTKRKSQIQTYLEHNEGAGLQHLALMSEDI
FRTLREMRKRSSIGGFDFMPSPPPTYYQNLKKRVGDVLSDDQIKECEELG
ILVDRDDQGTLLQIFTKPLGDRPTIFIEIIQRVGCMMKDEEGKAYQSGGC
GGFGKGNFSELF

Ligand information

• Ligand ID: FE2
• InChI: InChI=1S/Fe/q+2
• InChIKey: CWYNVVGOOAEACU-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Fe+2]
  CACTVS 3.341: [Fe++]
• Formula: Fe
• Name: FE (II) ION
• DrugBank: DB14510
• PDB chain: 1sp9 Chain A Residue 446

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1sp9 The crystal structures of Zea mays and Arabidopsis 4-Hydroxyphenylpyruvate Dioxygenase
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): H226 H308 E394
• Binding residue (residue number reindexed from 1): H171 H242 E328
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.13.11.27: 4-hydroxyphenylpyruvate dioxygenase.

Gene Ontology

Molecular Function

• GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity
• GO:0005506 iron ion binding
• GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding
• GO:0051213 dioxygenase activity

Biological Process

• GO:0006559 L-phenylalanine catabolic process
• GO:0006572 tyrosine catabolic process
• GO:0009072 aromatic amino acid metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1sp9, PDBe:1sp9, PDBj:1sp9
• PDBsum: 1sp9
• PubMed: 15084729
• UniProt: P93836|HPPD_ARATH 4-hydroxyphenylpyruvate dioxygenase (Gene Name=HPD)