Structure of PDB 1slc Chain A Binding Site BS01

Receptor Information

>1slc Chain A (length=134) Species: 9913 (Bos taurus)

ACGLVASNLNLKPGECLRVRGEVAADAKSFLLNLGKDDNNLCLHFNPRFN
AHGDVNTIVCNSKDAGAWGAEQRESAFPFQPGSVVEVCISFNQTDLTIKL
PDGYEFKFPNRLNLEAINYLSAGGDFKIKCVAFE

Ligand information

• Ligand ID: GAL
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6-/m1/s1
• InChIKey: WQZGKKKJIJFFOK-FPRJBGLDSA-N
• SMILES:
  CACTVS 3.370: OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O
  OpenEye OEToolkits 1.7.2: C(C1C(C(C(C(O1)O)O)O)O)O
  CACTVS 3.370: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  ACDLabs 12.01: OC1C(O)C(OC(O)C1O)CO
  OpenEye OEToolkits 1.7.2: C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
• Formula: C6 H12 O6
• Name: beta-D-galactopyranose;
  beta-D-galactose;
  D-galactose;
  galactose
• ChEMBL: CHEMBL300520
• ZINC: ZINC000002597049
• PDB chain: 1slc Chain E Residue 5

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1slc Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides.
• Resolution: 2.15 Å
• Binding residue (original residue number in PDB): H44 H52 N61 E71
• Binding residue (residue number reindexed from 1): H44 H52 N61 E71
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0030246 carbohydrate binding
• GO:0030395 lactose binding
• GO:0043236 laminin binding

Biological Process

• GO:0006915 apoptotic process

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm

External links

• PDB: RCSB:1slc, PDBe:1slc, PDBj:1slc
• PDBsum: 1slc
• PubMed: 7773775
• UniProt: P11116|LEG1_BOVIN Galectin-1 (Gene Name=LGALS1)