Structure of PDB 1sje Chain A Binding Site BS01

Receptor Information
>1sje Chain A (length=180) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFA
SFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREP
NVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLP
FLPSTEDVYDCRVEHWGLDEPLLKHWEFDA
Ligand information
>1sje Chain C (length=15) Species: 11683 (Human immunodeficiency virus type 1 (Z2/CDC-Z34 ISOLATE)) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PEVIPMFSALSEGAT
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1sje A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		Q9 F51 A52 S53 F54 E55 N62 V65 D66 N69 I72
Binding residue
(residue number reindexed from 1)		Q7 F49 A50 S51 F52 E53 N60 V63 D64 N67 I70
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:1sje, PDBe:1sje, PDBj:1sje
PDBsum1sje
PubMed15331779
UniProtP01903|DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain (Gene Name=HLA-DRA)

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