Structure of PDB 1shw Chain A Binding Site BS01

Receptor Information
>1shw Chain A (length=138) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERY
VLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLG
FEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCM
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1shw Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1shw Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
Resolution2.2 Å
Binding residue
(original residue number in PDB)		H53 D55
Binding residue
(residue number reindexed from 1)		H22 D24
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046875 ephrin receptor binding
Biological Process
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:1shw, PDBe:1shw, PDBj:1shw
PDBsum1shw
PubMed15107857
UniProtO08543|EFNA5_MOUSE Ephrin-A5 (Gene Name=Efna5)

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