Structure of PDB 1sh3 Chain A Binding Site BS01

Receptor Information

>1sh3 Chain A (length=502) Species: 11983 (Norwalk virus)

GTYCGAPILGPGSAPKLSTKTKFWRSSTAPLPPGTYEPAYLGGKDPRVKG
GPSLQQVMRDQLKPFTEPRGKPPKPSVLEAAKKTIINVLEQTIDPPDKWS
FAQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLADQASKANLMFEEGK
NMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFGGLMDE
LKTHCVTLPIRVGMNMNEDGPIIFERHSRYRYHYDADYSRWDSTQQRAVL
AAALEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFTISINEGLPSGVPCT
SQWNSIAHWLLTLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDP
EKLTAKLKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGK
LEQSSILRQMYWTRGPNHEDPSETMIPHSQRPIQLMSLLGEAALHGPAFY
SKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDLSTWEGDRNLAPSFVN
ED

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1sh3 Chain A Residue 600

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1sh3 Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft.
• Resolution: 2.95 Å
• Binding residue (original residue number in PDB): D240 D344 T389
• Binding residue (residue number reindexed from 1): D235 D339 T384
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.4.22.66: calicivirin.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:1sh3, PDBe:1sh3, PDBj:1sh3
• PDBsum: 1sh3
• PubMed: 14764591
• UniProt: Q70ET3