Structure of PDB 1sd3 Chain A Binding Site BS01

Receptor Information
>1sd3 Chain A (length=251) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYE
IRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDF
SKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKI
STYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRN
CNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW
R
Ligand information
Ligand IDSYM
InChIInChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/p-1/t3-,4+/m1/s1
InChIKeyKRKRAOXTGDJWNI-DMTCNVIQSA-M
SMILES
SoftwareSMILES
CACTVS 3.341C[CH](C[CH](N)C([O-])=O)C(O)=O
ACDLabs 10.04[O-]C(=O)C(N)CC(C(=O)O)C
OpenEye OEToolkits 1.5.0C[C@H](C[C@@H](C(=O)[O-])N)C(=O)O
CACTVS 3.341C[C@H](C[C@H](N)C([O-])=O)C(O)=O
OpenEye OEToolkits 1.5.0CC(CC(C(=O)[O-])N)C(=O)O
FormulaC6 H10 N O4
Name2S,4R-4-METHYLGLUTAMATE
ChEMBL
DrugBankDB03425
ZINC
PDB chain1sd3 Chain A Residue 998 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1sd3 Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		Y61 P89 A91 R96 V138 G141 A142 T143 E191
Binding residue
(residue number reindexed from 1)		Y59 P87 A89 R94 V136 G139 A140 T141 E189
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1sd3, PDBe:1sd3, PDBj:1sd3
PDBsum1sd3
PubMed15721240
UniProtP42260|GRIK2_RAT Glutamate receptor ionotropic, kainate 2 (Gene Name=Grik2)

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