Structure of PDB 1s70 Chain A Binding Site BS01

Receptor Information
>1s70 Chain A (length=309) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQP
ILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQS
LETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWK
TFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGL
LCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQV
VEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSE
KKAKYQYGG
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1s70 Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1s70 Structural basis of protein phosphatase 1 regulation
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D92 N124 H173 H248
Binding residue
(residue number reindexed from 1)		D92 N124 H173 H248
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D64 H66 D92 D95 R96 N124 H125 H173 R221 H248
Catalytic site (residue number reindexed from 1) D64 H66 D92 D95 R96 N124 H125 H173 R221 H248
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
3.1.3.53: [myosin-light-chain] phosphatase.
Gene Ontology
Molecular Function
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0017018 myosin phosphatase activity
GO:0046872 metal ion binding
GO:0050115 myosin-light-chain-phosphatase activity
Biological Process
GO:0005977 glycogen metabolic process
GO:0030155 regulation of cell adhesion
GO:0032922 circadian regulation of gene expression
GO:0042752 regulation of circadian rhythm
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0072357 PTW/PP1 phosphatase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1s70, PDBe:1s70, PDBj:1s70
PDBsum1s70
PubMed15164081
UniProtP62207|PP1B_CHICK Serine/threonine-protein phosphatase PP1-beta catalytic subunit (Gene Name=PPP1CB)

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