Structure of PDB 1s1e Chain A Binding Site BS01

Receptor Information
>1s1e Chain A (length=181) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLEQLEAQTNFTKRELQVLYRGFKNECPSGVVNEETFKQIYAQFFPHGDA
STYAHYLFNAFDTTQTGSVKFEDFVTALSILLRGTVHEKLRWTFNLYDIN
KDGYINKEEMMDIVKAIYDMMGKYTYPVLKEDTPRQHVDVFFQKMDKNKD
GIVTLDEFLESCQEDDNIMRSLQLFQNVMVE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1s1e Chain A Residue 225 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1s1e Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D135 N137 D139 Y141 E146
Binding residue
(residue number reindexed from 1)		D98 N100 D102 Y104 E109
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
Biological Process
GO:0006936 muscle contraction
GO:0007268 chemical synaptic transmission
GO:0008016 regulation of heart contraction
GO:0071805 potassium ion transmembrane transport
GO:0086009 membrane repolarization
GO:0097623 potassium ion export across plasma membrane
GO:1901379 regulation of potassium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0009898 cytoplasmic side of plasma membrane
GO:0030425 dendrite
GO:0034702 monoatomic ion channel complex
GO:0042995 cell projection
GO:0045202 synapse
GO:0071196 Kv4.3-KChIP1 channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1s1e, PDBe:1s1e, PDBj:1s1e
PDBsum1s1e
PubMed14980207
UniProtQ9NZI2|KCIP1_HUMAN A-type potassium channel modulatory protein KCNIP1 (Gene Name=KCNIP1)

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