Structure of PDB 1s0u Chain A Binding Site BS01

Receptor Information
>1s0u Chain A (length=391) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQAEVNIGMVGHVDHGKTSLTKALTGVWTDRGISIRLGYADCEIRKCPQC
GTYTTKPRCPNCLAETEFLRRVSFVDSPGHETLMATMLSGASLMDGAILV
IAANEPCPQPQTKEHLMALEILGIDKIIIVQNKIDLVDEKQAEENYEQIK
EFVKGTIAENAPIIPINIDVLLKAIQDFIPTPKRDPDATPRMYVARSFDI
NKPGTEIKDLKGGVLGGAIIQGVFKVGDEIEIRPGIKVTEGNKTFWKPLT
TKIVSLAAGNTILRKAHPGGLIGVGTTLDPYLTKSDALTGSVVGLPGTLP
PIREKITIRANLLDRVVGTKEELKIEPLRTGEVLMLNIGTATTAGVITSA
RGDIADIKLKLPICAEIGDRVAISRRVGSRWRLIGYGTIEG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1s0u Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1s0u X-ray Structure of Translation Initiation Factor eIF2gamma: IMPLICATIONS FOR tRNA AND eIF2alpha BINDING.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		C87 C90 C99
Binding residue
(residue number reindexed from 1)		C47 C50 C59
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D47 K50 T51 S74 H120
Catalytic site (residue number reindexed from 1) D14 K17 T18 S34 H80
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation

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Molecular Function
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Biological Process
External links
PDB RCSB:1s0u, PDBe:1s0u, PDBj:1s0u
PDBsum1s0u
PubMed14688270
UniProtQ58657|IF2G_METJA Translation initiation factor 2 subunit gamma (Gene Name=eif2g)

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