Structure of PDB 1rz5 Chain A Binding Site BS01

Receptor Information

>1rz5 Chain A (length=309) Species: 2743 (Marinobacter nauticus)

DNLMERANSMFEPIPKYPPVIDGNELTQAKVELGKMEFFEPRLSSSHLIS
CNTCHNVGLGGDDELPTSIGHGWQKGPRNSPTVFNAVFNAAQFWDGRAKG
PVQAGVEMSSTPDRVVATLKSMPEYIERFEDAFPGQENPVTFDNMAVAIE
AYEATLITPEAPFDKYLRGDTSALNESEKEGLALFMDRGCTACHSGVNLG
GQNYYPFGLVAKKGRFSVTETASDEYVFRASPLRNIELTAPYFHSGAVWS
LEEAVAVMGTAQLGTELNNDEVKSIVAFLKTLTGNVPEVTYPVLPPSTAN
TPKPVDMIP

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1rz5 Chain A Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1rz5 Structural basis for the mechanism of Ca(2+) activation of the di-heme cytochrome c peroxidase from Pseudomonas nautica 617.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): N79 T256 P258
• Binding residue (residue number reindexed from 1): N79 T239 P241
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E114
• Catalytic site (residue number reindexed from 1): E107
• Enzyme Commision number: 1.11.1.5: cytochrome-c peroxidase.

Gene Ontology

Molecular Function

• GO:0004130 cytochrome-c peroxidase activity
• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0098869 cellular oxidant detoxification

Cellular Component

• GO:0042597 periplasmic space

External links

• PDB: RCSB:1rz5, PDBe:1rz5, PDBj:1rz5
• PDBsum: 1rz5
• PubMed: 15274917
• UniProt: P83787