Structure of PDB 1rtd Chain A Binding Site BS01

Receptor Information
>1rtd Chain A (length=554) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKI
GPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGL
KKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLP
QGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKD
SWTVNDICKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET
WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRET
KLGKAGYVTNKGRQKVVPLTDTTNQKTQLQAIYLALQDSGLEVNIVTDSQ
YALGIIQAQPDESESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDK
LVSA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1rtd Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		W24 F61 L74 V75 D76 R78 E89 Q91 I94 G152 N265 C280 R284 T286 K353 K374 R448 Q500
Binding residue
(residue number reindexed from 1)		W24 F61 L74 V75 D76 R78 E89 Q91 I94 G152 N265 C280 R284 T286 K353 K374 R448 Q500
Enzymatic activity
Catalytic site (original residue number in PDB) D110 V111 D185 D186 K220
Catalytic site (residue number reindexed from 1) D110 V111 D185 D186 K220
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1rtd, PDBe:1rtd, PDBj:1rtd
PDBsum1rtd
PubMed9831551
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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