Structure of PDB 1rrv Chain A Binding Site BS01

Receptor Information

>1rrv Chain A (length=401) Species: 31958 (Amycolatopsis orientalis)

MRVLLSVCGTRGDVEIGVALADRLKALGVQTRMCAPPAAEERLAEVGVPH
VPVGLPQHMMLQEGMPPPPPEEEQRLAAMTVEMQFDAVPGAAEGCAAVVA
VGDLAAATGVRSVAEKLGLPFFYSVPSPVYLASPHLPPAYDEPTTPGVTD
IRVLWEERAARFADRYGPTLNRRRAEIGLPPVEDVFGYGHGERPLLAADP
VLAPLQPDVDAVQTGAWLLSDERPLPPELEAFLAAGSPPVHIGFGSSSGR
GIADAAKVAVEAIRAQGRRVILSRGWTELVLPDDRDDCFAIDEVNFQALF
RRVAAVIHHGSAGTEHVATRAGVPQLVIPRNTDQPYFAGRVAALGIGVAH
DGPTPTFESLSAALTTVLAPETRARAEAVAGMVLTDGAAAAADLVLAAVG
R

Ligand information

>1rrv Chain C (length=7) Species: 31958 (Amycolatopsis orientalis)

LYNGGFI

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1rrv Crystal Structure of Vancosaminyltransferase Gtfd from the Vancomycin Biosynthetic Pathway: Interactions with Acceptor and Nucleotide Ligands
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): C8 G9 T10 M60 L61 Q62 M65 P67 L76 T80 D141 P143 N331 T332
• Binding residue (residue number reindexed from 1): C8 G9 T10 M60 L61 Q62 M65 P67 L76 T80 D141 P143 N331 T332

Enzymatic activity

• Enzyme Commision number: 2.4.1.322: devancosaminyl-vancomycin vancosaminetransferase.

Gene Ontology

Molecular Function

• GO:0008194 UDP-glycosyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0016758 hexosyltransferase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0017000 antibiotic biosynthetic process
• GO:0030259 lipid glycosylation
• GO:0033072 vancomycin biosynthetic process

External links

• PDB: RCSB:1rrv, PDBe:1rrv, PDBj:1rrv
• PDBsum: 1rrv
• PubMed: 15122882
• UniProt: Q9AFC7|GTFD_AMYOR Devancosaminyl-vancomycin vancosaminetransferase (Gene Name=gtfD)