Structure of PDB 1rn4 Chain A Binding Site BS01

Receptor Information

>1rn4 Chain A (length=100) Species: 5062 (Aspergillus oryzae)

ACDYTCGSNCYSSSDVSTAQAAGYKLHEDGETVGSNSYPHKYNNYEGFDF
SVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITATNNFVECT

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 1rn4 Chain A Residue 105

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1rn4 His92Ala mutation in ribonuclease T1 induces segmental flexibility. An X-ray study.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): Y38 H40 E58 R77 N98
• Binding residue (residue number reindexed from 1): Y38 H40 E58 R77 N94
• Annotation score: 3

Enzymatic activity

• Catalytic site (original residue number in PDB): Y38 H40 E58 D76 R77 T91 A92 F100
• Catalytic site (residue number reindexed from 1): Y38 H40 E58 D76 R77 T91 A92 F96
• Enzyme Commision number: 4.6.1.24: ribonuclease T1.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0004521 RNA endonuclease activity
• GO:0004540 RNA nuclease activity
• GO:0016829 lyase activity
• GO:0046589 ribonuclease T1 activity

Biological Process

• GO:0008150 biological_process

Cellular Component

• GO:0001411 hyphal tip
• GO:0030428 cell septum

External links

• PDB: RCSB:1rn4, PDBe:1rn4, PDBj:1rn4
• PDBsum: 1rn4
• PubMed: 1314902
• UniProt: P00651|RNT1_ASPOR Guanyl-specific ribonuclease T1 (Gene Name=rntA)