Structure of PDB 1rkj Chain A Binding Site BS01

Receptor Information
>1rkj Chain A (length=175) Species: 10036 (Mesocricetus auratus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMVEGSESTTPFNLFIGNLNPNKSVAELKVAISELFAKNDLAVVDVRT
GTNRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGRDSKKVRAAR
TLLAKNLSFNITEDELKEVFEDALEIRLVSQDGKSKGIAYIEFKSEADAE
KNLEEKQGAEIDGRSVSLYYTGEKG
Ligand information
>1rkj Chain B (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggaugccucccgagugcaucc
<<<<<<.........>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1rkj Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target.
ResolutionN/A
Binding residue
(original residue number in PDB)		F17 R49 T52 F56 Y58 K89 R91 D92 K94 K95 L103 K105 R127 V129 K136 I138 Y140
Binding residue
(residue number reindexed from 1)		F17 R49 T52 F56 Y58 K89 R91 D92 K94 K95 L103 K105 R127 V129 K136 I138 Y140
Binding affinityPDBbind-CN: Kd=1.1uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:1rkj, PDBe:1rkj, PDBj:1rkj
PDBsum1rkj
PubMed15033352
UniProtP08199|NUCL_MESAU Nucleolin (Gene Name=NCL)

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