Structure of PDB 1rk8 Chain A Binding Site BS01

Receptor Information
>1rk8 Chain A (length=87) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PQRSVGWILFVTSIHEEAQEDEIQEKFCDYGEIKNIHLNLDRRTGFSKGY
ALVEYETHKQALAAKEALNGAEIMGQTIQVDWCFVKG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1rk8 Chain A Residue 9002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1rk8 Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex
Resolution1.9 Å
Binding residue
(original residue number in PDB)		D87 E91
Binding residue
(residue number reindexed from 1)		D21 E25
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0007294 germarium-derived oocyte fate determination
GO:0007310 oocyte dorsal/ventral axis specification
GO:0007314 oocyte anterior/posterior axis specification
GO:0007317 regulation of pole plasm oskar mRNA localization
GO:0008380 RNA splicing
GO:0045451 pole plasm oskar mRNA localization
GO:0046595 establishment of pole plasm mRNA localization
GO:0051028 mRNA transport
GO:0051170 import into nucleus
GO:0051663 oocyte nucleus localization involved in oocyte dorsal/ventral axis specification
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0035145 exon-exon junction complex
GO:0042564 NLS-dependent protein nuclear import complex
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1rk8, PDBe:1rk8, PDBj:1rk8
PDBsum1rk8
PubMed14968132
UniProtQ9V535|RBM8A_DROME RNA-binding protein 8A (Gene Name=tsu)

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